Marcus Analysis of Ambident Reactivity

Angew. Chemie, 2010, 49, 5165–5169 published on 12.06.2010
Angew. Chem.
A better approach to ambident reactivity: The principle of hard and soft acids and bases (HSAB) cannot rationalize the reactivities of even the prototypical ambident nucleophiles shown in the picture. Marcus theory, which describes activation energies by a combination of intrinsic and thermodynamic terms, is a superior alternative.
TU München