i-PrI Acceleration of Negishi Cross-Coupling Reactions

Org. Lett., 2010, 12, 2702-2705 published on 18.05.2010
Org. Lett.
The Negishi cross-coupling of arylzinc reagents with various bromoanilines is accelerated by the presence of i-PrI (1 equiv) and furnished the expected biaryls within 5-12 min reaction time at 25 °C. Arylzinc reagents can also be cross-coupled under these conditions with a range of aryl bromides bearing an enolizable ester or acidic benzylic protons.
TU München