Norbornenes in Inverse Electron-Demand Diels–Alder Reactions

Chem. Eur. J., 2013, 40, 13309-13312 published on 11.09.2013
Chem. Eur. J.
Significant differences in the reactivity of norbornene derivatives in the inverse electron-demand Diels–Alder reaction with tetrazines were revealed by kinetic studies. Substantial rate enhancement for the exo norbornene isomers was observed. Quantum-chemical calculations were used to rationalize and support the observed experimental data.
TU München