Ion-Pairing of Phosphonium Salts in Solution: C[BOND]H⋅⋅⋅Halogen and C[BOND]H⋅⋅⋅π Hydrogen Bonds

Chem. Eur. J., 2013, 19, 14612-14630 published on 06.09.2013
Chem. Eur. J.
The 1H NMR chemical shifts of the C(α)H protons of arylmethyl triphenylphosphonium ions in CD2Cl2 solution strongly depend on the counteranions X. The values for the benzhydryl derivatives Ph2CHPPh3+ X, for example, range from δH=8.25 (X=Cl) over 6.23 (X=BF4) to 5.72 ppm (X=BPh4). Similar, albeit weaker, counterion-induced shifts are observed for the ortho-protons of all aryl groups. Concentration-dependent NMR studies show that the large shifts result from the deshielding of the protons by the anions, which decreases in the order Cl > Br ≫ BF4 > SbF6. For the less bulky derivatives PhCH2PPh3+ X, we also find CH⋅⋅⋅Ph interactions between C(α)H and a phenyl group of the BPh4 anion, which result in upfield NMR chemical shifts of the C(α)H protons. These interactions could also be observed in crystals of (p-CF3-C6H4)CH2PPh3+ BPh4. However, the dominant effects causing the counterion-induced shifts in the NMR spectra are the CH⋅⋅⋅X hydrogen bonds between the phosphonium ion and anions, in particular Cl or Br. This observation contradicts earlier interpretations which assigned these shifts predominantly to the ring current of the BPh4 anions. The concentration dependence of the 1H NMR chemical shifts allowed us to determine the dissociation constants of the phosphonium salts in CD2Cl2 solution. The cation–anion interactions increase with the acidity of the C(α)H protons and the basicity of the anion. The existence of CH⋅⋅⋅X hydrogen bonds between the cations and anions is confirmed by quantum chemical calculations of the ion pair structures, as well as by X-ray analyses of the crystals. The IR spectra of the Cl and Br salts in CD2Cl2 solution show strong red-shifts of the CH stretch bands. The CH stretch bands of the tetrafluoroborate salt PhCH2PPh3+ BF4 in CD2Cl2, however, show a blue-shift compared to the corresponding BPh4 salt.
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