Mechanism of Acetylaminofluorene-dG Induced Frameshifting by

Chembiochem, 2010, 11, 2534-2537 published on 09.11.2010
Frameshift mutations: Bulky adduct DNA lesions, such as the C8-acetylaminofluorene dG lesion (AAF-dG), induce frameshift mutations if they are placed in special gene sequences. With the help of synthetic AAF-dG lesions inserted into different repetitive frameshift-prone sequences, the molecular basis of the −I, −II, and −III frameshifting events was determined.
TU München