Oxidative Amination of Cuprated Pyrimidine and Purine Derivatives

Org. Lett., 2008, 10, 1715-1718 published on 09.04.2008
Org. Lett.
Using regioselective cuprations (via magnesiations), various primary, secondary and tertiary aminated pyrimidine and purine derivatives were prepared by the oxidative coupling of lithium amidocuprates using chloranil. DNA and RNA units such as aminated uracil or thymine, and adenine, as well as a CDK inhibitor, purvalanol A, were all obtained under mild conditions and satisfactory yields.
TU München