Translesion Synthesis of 1,3-GTG Cisplatin DNA Lesions

ChemBioChem, 2010, 11, 1521-1524 published on 26.07.2010
Low-fidelity polymerases: Cells can copy genetic material even in the presence of DNA lesions. Here we show that this bypass process is also possible for the strongly helix disturbing cisplatin 1,3-GTG lesion. A key polymerase involved in the translesion synthesis (TLS) process is Pol η. The results have implication for the resistance problem associated with cisplatin chemotherapy.
TU München