Development of a DNA Photoaffinity Probe for the Analysis of 8-OxodG-Binding Proteins in a Human Proteome

ChemBioChem, 2010, 11, 1345-1349 published on 10.06.2010
Finding DNA repair factors: A comparative study with DNA probes containing 8-oxodG and bearing different photo-crosslinking moieties found that a triethyleneglycol-trifluoromethyl-phenyldiazirine system was excellent for the labeling of DNA repair factors. This probe was used for the activity-based and selective labeling of different DNA repair factors in a human HCT-116 nuclear proteome.
TU München