Crystal Structure and Mechanism of a DNA (6-4) Photolyase

Angew. Chem. Int. Ed., 2008, 47, 10076-10080 published on 27.10.2008
Angew. Chem. Int. Ed.

Before and after: Crystal structures of the DNA (6-4) photolyase from D. melanogaster—one structure in complex with DNA containing a (6-4) lesion (see picture) and one in which the lesion has been repaired—provide new insight into lesion recognition and repair. The proposed mechanism for light-induced, electron-transfer-based repair of the (6-4) lesion does not proceed via an oxetane intermediate.

TU München